ABOUT

Facts & Figures

ABOUT01

Neurological disorders

are a global society problem

  • 7% of the population affected
  • No curable neurological disease
  • Yearly cost > $800 billions
ABOUT02

Challenges of drug discovery

for neurological disorders

  • 76% drug candidates fail in phase 3 after 5 to 8 years of research.
  • Need to overcome in vitro models limitations to quickly identify safer and more effective drugs
SYNAXYS

A new depth
to your preclinical R&D studies

Pioneer in neuro-engineering, Synaxys proposes 5D-brain. The first reliable human in vitro model of the nervous system for functional preclinical studies.

 

5 accessible dimensions (X, Y, Z, time, activity) to replace animal experimentation & to enhance preclinical R&D results.

 

  • Reliable substitutes to organoids
  • Measure in vivo like neuronal activity in vitro
  • Mimic specific neuropathology disorders
  • Enable the identification of targets, effects and regulation

Live confocal microscopy image of human neurons grown in 3D; each neuron is engineered to express a specific fluorescent protein
© Synaxys

SYNAXYS

The unique properties of 5D-brains

PICTO_ROBUST

01

ROBUST & REPRODUCIBLE

Standardized high reproducibility hIPSC differentiation processes leading to identical physiological properties

PICTO_FAST

02

FAST IMPLEMENTATION

5D-brains mature 4 times faster than organoids current 3D models, and deliver reliable preclinical data in less than 3 weeks

PICTO_MULTISCALE

03

MULTI-SCALE
NEURONAL ACTIVITY RECORDING

5D-brain is the sole 3D model capable of monitoring individual neurons’ activity over the whole network throughout all its developmental stages

SYNAXYS

Performance grounded
in multidisciplinary expertise

PICTO_02

01

TISSUE ENGINEERING

Proprietary processes to obtain in vivo like human neuronal networks in vitro

PICTO_04

02

BIOENGINEERING TOOLS AND INSTRUMENTATION

5D-brains are in vitro models tailor made to address physiological and pharmacological questions

PICTO_05

03

BIG DATA ANALYSIS

Global comprehensive analysis of the nervous system response to predict: target, dose effects, efficacy and regulation pathways

Services

Innovative, animal free,
and cost-effective models

Description

 

Synaxys realizes preclinical assays and R&D projects to rapidly predict the response of the human nervous system before starting clinical trials.

 

Our platform offers a wide range of electrophysiological assays with supporting microscopy, genomic and proteomic data for a comprehensive analysis. Using our proprietary 5D-brain models, we propose custom pharmacology and toxicology screens on neural functions to identify the targets and actions of a compound.

 

Unique insight on human neurological diseases

 

Synaxys 5D-brain models are long lived and composed of all the neuronal cell types with their regulating elements. These intrinsic properties enable them to bring pertinent data on:

Microscopy image of a 4 week old 3D neuronal network in contact with a 60 electrodes MEA chip; axons (green), synapses (red), nuclei (blue).
© Synaxys

Bursting neuronal networks, Excitatory and inhibitory activity.

Identifiable D1, D2, D3 dopamergic activity

Myelinated axons

Monitoring of neuronal networks developmental steps

Monitoring of the functional aging process

Offer:

 

Synaxys offers three complementary levels of services

 

  • Pilot Tests:
    Characterization of the dose response for your compounds compared to reference chemicals on a healthy mature 3D human neuronal network
  • Neuro-pharmocology studies:
    • Identification of the biological targets of your compounds
    • Determination the specific characteristics of your compounds compared to known drugs with similar targets
  • Full R&D projects:
    Evaluation of the therapeutic potential of a compound with 5D-brain disease models. Two models are currently available : healthy reference and epileptic model.

Modality:

 

Synaxys operates as a contract research organization

 

  • Custom designed services:
    We design and realize studies to evaluate and select lead compounds for your applications to provide the most exhaustive and accurate results, and we deliver a thorough confidential report directly usable for decision-making.
  • R&D partnerships with public or private institutions:
    We participate in collaborative R&D projects as partner to answer research calls, or as coordinator to design and manage your R&D projects.
TESTIMONIALS

What they say about us

« Working with Synaxys has been very beneficial. Their breakthrough model has helped us define and back marketing arguments for our health supplements. These studies have contributed to a significant sales increase. »
« High throughput screening models that do not need fluorescent labels but report metabolic and electrical signals is greatly needed by the both scientific and pharma industry. Thus success of Synaxys’s project will have many scientific, economic impact with potential for social impact for reducing the burden of neurodegenerative disease on society. »
AGENCE NATIONALE
DE LA RECHERCHE
Team

Who we are

Founders
IDSOPHIE

Sophie PAUTOT

Co-founder

Sophie Pautot (PhD Applied Physics from Harvard, HDR) has a multi-disciplinary training and more than 15 years of experience leading high impact cross-disciplinary projects in neuroscience. She pioneered the processes that serves as scientific foundation to Synaxys 5D-brains.

IDMICHEL

Michel FARENG

Co-founder

Michel Fareng (graduated from HEC) is a serial entrepreneur. For decades, he was involved in sport management, culture and education. Today he focuses on sustainable activities, environment and health issues.

Photos : Lionel Pesqué

Founders statement
We founded Synaxys because we believe that the in vivo like properties of our 5D-brains can replace animal experiments in preclinical studies and help pharmaceutical laboratories significantly improve the quality of their preclinical results to accelerate the discovery of therapeutic solution for neurological disorders.

Highlights:

 

  • 07/2020 Synaxys welcomes a new business partner
  • 06/2020 Be a Boss Occitanie award
  • 05/2020 CREALIA is supporting us
  • 04/2020 Initiative Haute Garonne is supporting us
  • 11/2019 Invited talk at the Neurofluidics 2019 conference, Montpellier
  • 10/2019 Launching of the ANR-PRCE coordinated by Synaxys
  • 09/2019 Synaxys joined Eurobiomed
  • 06/2019 Synaxys obtains the JEI label
  • 12/2018 License agreement with the CNRS and SATT-TTT
  • 03/ 2018 Kickoff of Synaxys’ activities
  • 11/2017 Housing agreement with the CNRS and the ITAV
Our partners
Contact

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